Journal article
A large-scale ENIGMA multisite replication study of brain age in depression
Laura KM Han, Richard Dinga, Ramona Leenings, Tim Hahn, James H Cole, Lyubomir I Aftanas, Alyssa R Amod, Bianca Besteher, Romain Colle, Emmanuelle Corruble, Baptiste Couvy-Duchesne, Konstantin V Danilenko, Paola Fuentes-Claramonte, Ali Saffet Gonul, Ian H Gotlib, Roberto Goya-Maldonado, Nynke A Groenewold, Paul Hamilton, Naho Ichikawa, Jonathan C Ipser Show all
Neuroimage: Reports | Elsevier BV | Published : 2022
Abstract
Background: Several studies have evaluated whether depressed persons have older appearing brains than their nondepressed peers. However, the estimated neuroimaging-derived “brain age gap” has varied from study to study, likely driven by differences in training and testing sample (size), age range, and used modality/features. To validate our previously developed ENIGMA brain age model and the identified brain age gap, we aim to replicate the presence and effect size estimate previously found in the largest study in depression to date (N = 2126 controls & N = 2675 cases; +1.08 years [SE 0.22], Cohen’s d = 0.14, 95% CI: 0.08–0.20), in independent cohorts that were not part of the original study..
View full abstractGrants
Awarded by Japan Society for the Promotion of Science